| Arts & Entertainment |
| Nick Adams : Nanticoke Actor. Star of "The Rebel", a cowboy show from the 1950's and 60's. |
| James DeBello : Attended Shenandoah Valley HS Actor. Roles in "Detroit Rock City" (movie), "My Guide to Becoming a Rock Star" (WB). Small part in "American Pie". Born in Connecticut; attended Shenandoah Valley Jr/Sr HS in the mid 1990's |
| Danny "Freebo" Friedberg : Mahanoy City Musician. Longtime bass player for Bonnie Raitt, now doing solo stuff. See freebo, and Schuylkill Online article. |
| Nancy Grigor : Edwardsville; The Prell Girl! Star of Prell shampoo commercials in the late 1960's. |
| Joseph L. Mankeiwicz : Wilkes-Barre; Oscar for Best Director and Best Screenplay Adaptation, "All About Eve", 1950 |
| Rosalyn Menon : Hazleton; Miss Pennsylvania 2001 |
| Paul Plishka : Old Forge; Opera Singer |
| Maria Powers : (from?); Opera Singer |
| Jolly Jack Robel : Shenandoah; Polka Musician, wrote the famous "Beer Barrel Polka". "Roll out the barrels..." |
| Writers |
| Joseph Awad : Shenandoah; Poet Laureate, Commonwealth of Virginia |
| Ham Fisher : Wilkes-Barre; Cartoonist ("Joe Palooka") |
| Jane Jacobs : Scranton; Author, Urban Planner |
| Military & Government |
| Admiral Joel Thompson Boone : St. Clair Winner of the Congressional Medal Of Honor (U.S. Navy, WWI, France) |
| Admiral Herbert G. Hopwood : Shamokin; Commander-in-chief of the U.S. Pacific Fleet 1958-1960. |
| Mary Jo Kopechne : Plymouth; Tragically killed in Ted Kennedy's car at Chappaquiddick |
| Richard Marcinko : Carbon County; Founder and first commanding officer of U.S. Navy SEAL TEAM 6 and RED CELL (counter-terrorist units) |
| General Jerry O'Malley : Carbondale; Former commander, U.S. Air Force Tactical Air Command |
| Harold Parfitt : Coaldale; Governor, Panama Canal Zone |
| John A. Walker Jr. : Scranton; Soviet Spy |
| Lt. Gen. John J. Yeosock : Plains Desert Storm Commander |
| Science & Industry |
| David Bohm : Wilkes-Barre; Physicist |
| Amedeo Obici : Wilkes-Barre; Founded a fruit and peanut stand that grew to become "Planter's Peanuts" |
| B. F. Skinner : Susquehanna; Psychologist |
| Alfred Zmuda : Shenandoah; Scientist. Calculated trajectory landing tables for moon landing. |
| Glynn Lunney : Old Forge; NASA flight director for Apollo 11. Also worked on Apollo 13 team. |
| Sports |
| Joe Balsis : Minersville; Champion Billiards Player |
| Sam Brazinsky : Kulpmont; Pro Football Player (Buffalo Bills) |
| George Dillman : Schuylkill Haven, Pottsville ; National Karate Champion and Instructor. |
| Jack Dolbin : Pottsville; Pro Football Player (Denver Broncos) |
| Raghib (Rocket) and Quadry Ishmael : Wilkes-Barre; Pro Football Players |
| Norm Larker : Beaver Meadows; Pro Baseball Player |
| Joe Madden : Hazleton; Baseball Manager, Anaheim Angels |
| Tom Matchick : Hazleton; Pro Baseball Player |
| Ron Mattes : Ringtown; Pro Football Player |
| Dan Sekanovich : West Hazleton; College and Pro Football Coach |
| Greg Skrepanick : Hanover Township; Pro Football Player |
| Jimmy Spencer : Berwick; NASCAR driver ("Mr. Excitement") |
| Bob Tucker : Hazleton; Pro Football Player |
| Frank Zane : Edwardsville; Bodybuilder; former Mr. America or Mr. Universe. |